Advances in Men’s Sexual Health: The Role of Genetics

• 26 March 2025
• Mr. Leon Almashan

Last updated on March 26, 2025

The complex relationship between genetics and men’s sexual well-being has garnered significant attention in recent years. Exploring how genetic factors may influence various aspects of male sexual health provides valuable insights into common concerns. This page delves into the latest research on the genetic components associated with these conditions.

Genetics and Erectile Dysfunction

One significant breakthrough in the study of ED is the discovery of a genetic variant near the SIM1 gene.  Research involving over 36,649 men identified a specific genetic variant associated with a 26% increased likelihood of experiencing erectile dysfunction (ED) compared to the general male population. However, genetics is just one aspect of ED risk. Other significant factors include age, obesity, and underlying conditions such as diabetes. Additionally, smoking or a history of smoking further elevates the risk of developing ED.

While genetic predisposition plays a role, a study of middle-aged men indicated that genetics alone accounted for ED in approximately one-third of cases.

Genetics and Peyronie’s Disease

Research into the genetic underpinnings of PDPeyronie’s disease has yielded inconclusive results so far. However, several factors suggest a potential link. PD is thought to be more prevalent among Caucasian men than in other ethnic groups, a pattern often seen in diseases with a founder mutation, such as Cystic Fibrosis.

PD is characterised as a fibroproliferative disease, and it exhibits a robust comorbidity of around 20% with Dupuytren disease. In PD, fibrous plaque develops in the envelope that stretches along the penis, providing stability during erections. This plaque causes curvature or indentation. In contrast, Dupuytren disease manifests as knots of tissue beneath the skin, leading to finger flexion and bending.

Genetics and Premature Ejaculation

In the realm of PE, researchers have identified the involvement of three types of genes that influence the timing of ejaculation. Men with the LL gene tend to ejaculate roughly twice as quickly as those with SS or SL genes.

This genetic variation sheds light on the biological mechanisms contributing to rapid ejaculation.

Treatments for Men’s Sexual Health Issues

Men’s sexual issues can cause many men immense suffering. But those who consulted us went away with a happy face. That’s because the revolutionary non-invasive treatments which we provide to treat various male sexual issues like ED, PD or PE, are extremely effective.

Our unique combination of treatments including Focused Shockwave Therapy (FSWT), Extracorporeal MagnetoTransduction Therapy (EMTT) and NanoVi are capable of breaking down penile plaques, improving blood flow within penile tissues, speeding up the healing process and improving the immune system of body.

For PE patients we provide state-of-the-art pelvic floor muscle therapy, which enables men to undertake approximately 28,500 pelvic floor exercises in just 30 minutes. Moreover, all of our treatments are completely safe for most men and don’t have any major side-effects.

Men’s Sexual Health and Genetics FAQs